It has been shown in many different instances that there is a correlation between leptin and insulin resistance. In fact, previous studies have shown them to be highly correlated. One study, posted on Nature.com, serves as a good example of their relationship. They have found that, when compared, insulin sensitive men have lower liptin levels than insulin resistant men. This example shows how leptin levels may play a role somehow in how metabolic conditions come about.

Liptin and insulin work together in controlling the extent and rate of your metabolism. Insulin works at the cellular level, telling the cells whether to burn or store fat from sugar or to utilize it for energy. Insulin resistance occurs overtime because your cells adjust to high blood sugar levels by not reacting to the insulin. This causes the pancreas to produce more insulin, basically ‘to try’ and get the cells to react. …