Approved in 2007 as a combination of sitagliptin (Januvia) and metformin into a single tablet for treatment of diabetes, Janumet helps with glucose control in type 2 diabetics by simultaneously lowering glucose levels and acting as a DPP-4 inhibitor that reduces HbA1c levels. It also helps with weight loss. The two medications together can act on all three problems associates with type 2 diabetes – reduced insulin secretion, over-production of glucose and insulin resistance. The sitagliptin inhibits the DPP-4 enzyme, increasing the incretin hormone for more insulin production and release by the beta cells of the pancreas. It also works on the pancreatic alpha cells, slowing the release of glucagon. The metformin helps insulin sensitivity by increasing glucose uptake and utilization in the body’s muscles and tissues. It also decreases glucose production in the liver. For treating complications of diabetes, Janumet reduces post-meal blood sugar levels and also fasting glucose …